Gap junction intercellular communication (GJIC) is involved in the regulation of many
cellular processes. The gap junction channels are made up of connexins and the flow of …

In this study, we investigated whether the tumor promoters, 12-O-tetradecanoylphorbol-13-
acetate (TPA), phenobarbital (PB), and 1, 1-bis (p-chlorophenyl)-2, 2, 2-trichloroethane …

Abstract The phorbol ester, 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA), is a potent
inhibitor of gap junctional intercellular communication (GJIC). This inhibition requires …

Studies from several laboratories have shown that gap junctional communication can be
modulated by oncogenes, growth factors, as well as a variety of chemicals including tumor …

The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces transient
inhibition of gap junction intercellular communication (GJIC) in several cell types. The initial …

Disruption of gap junctional communication (GJC) by various compounds, including growth
factors and tumor promoters, is believed to be modulated by the phosphorylation of a gap …

Reversible down-regulation of gap junctional intercellular communication (GJIC) is
proposed to be an important cellular mechanism in tumor promotion. Gap junction function is …

Gap junction channels are made of a family proteins called connexins. The best-studied type
of connexin, Connexin43 (Cx43), is phosphorylated at several sites in its C-terminus. The …

We found that a rat liver epithelial cell line (IAR 20) expresses connexin 43, the major
cardiac gap‐junction protein, but not connexin 26 or connexin 32, major liver gap‐junction …

Gap junctional intercellular communication (GJIC) and the expression of gap junction
proteins (connexins) may be involved in growth regulation and neoplastic transformation …