Background Although accumulating evidence suggests a more extensive reduction of low-
density lipoprotein cholesterol (LDL-C), it is unclear whether a higher statin dose is more …

This study compared the effects of pravastatin and atorvastatin in a direct switch design to
evaluate differential impact of these statins on serum levels of lipids, lipoproteins and …

Atherosclerosis, especially when manifested as coronary artery disease (CAD), continues to
be the number one cause of mortality and morbidity in developed nations and will soon …

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The efficacy and safety profile of simvastatin and pravastatin across their most commonly
recommended dosage ranges were compared in a doubleblind, parallel, multicenter study …

The Atorvastatin Landmark Program: Global Investigators Meeting III was held June 1-3, in
Toronto, Canada. The purpose of the meeting was to update investigators on the current …

This randomized, placebo-controlled, double-masked, parallel-group trial assessed the
serum cholesterol—lowering effects of atorvastatin, a new 3-hydroxy-3-methylglutaryl …

BACKGROUND: Comparing the dose-response of a new drug to that of a previously studied
drug can aid in understanding their relative potencies. Two dose-finding studies addressed …

Background Previous studies indicated that a recently approved synthetic HMG-CoA
reductase inhibitor, atorvastatin, reduces LDL cholesterol and triglyceride. To assess the …

The lipid-lowering effects of rosuvastatin and atorvastatin were determined across their dose
ranges in a 6-week, randomized, double-blind trial. Three hundred seventy-four …