Anticellular immune suppression and plasma therapy have limited efficacy in C3G. Data
suggest that eculizumab may ameliorate disease in some C3G patients. The limited, recently …

Abstract 'C3 glomerulopathy'is a recent disease classification comprising several rare types
of glomerulonephritis (GN), including dense deposit disease (DDD), C3 glomerulonephritis …

Results Assessment of the alternative complement pathway showed that compared with
controls, patients with C3G had lower levels of serum C3 (P< 0.001 for both DDD and …

Abstract Background: C3 glomerulopathy (C3G) is caused by overactivity of the alternative
pathway of complement that results in bright glomerular C3 staining with minimal or no …

Results All patients presented with hematuria, associated with chronic renal failure and
proteinuria in five patients, three of whom had nephrotic syndrome. Five patients had …

C3 glomerulopathy is a recently described form of CKD. C3GN is a subtype of C3
glomerulopathy characterized by predominant C3 deposits in the glomeruli and is commonly …

Background: C3 glomerulopathy (C3G), a rare glomerular disease mediated by alternative
complement pathway dysregulation, is associated with a high rate of recurrence and graft …

Abstract Background C3 glomerulopathies (C3G) are characterized by uncontrolled
activation of the alternative pathway of complement. In most patients these diseases …

Recent advances in our understanding of the disease pathology of membranoproliferative
glomerulonephritis has resulted in its re-classification as complement C3 glomerulopathy …

Background Post-infectious glomerulonephritis (PIGN) is an immune complex-mediated
glomerular injury that typically resolves. Dominant C3 deposition is characteristic of PIGN …