[HTML][HTML] Hypoxia adipose stem cell-derived exosomes promote high-quality healing of diabetic wound involves activation of PI3K/Akt pathways

J Wang, H Wu, Y Peng, Y Zhao, Y Qin, Y Zhang… - Journal of …, 2021 - Springer
Refractory diabetic wounds can cause persistent inflammation and delayed healing due to
hypoxia. Currently, no optimal solution is available. Exosomes of adipose stem cells (ADSCs …

Engineered human adipose stem-cell-derived exosomes loaded with miR-21-5p to promote diabetic cutaneous wound healing

Q Lv, J Deng, Y Chen, Y Wang, B Liu… - Molecular …, 2020 - ACS Publications
Diabetic wounds are a worldwide health problem causing extremely heavy public health
burden and require effective treatment. Optimal strategies for treating nonhealing diabetic …

[HTML][HTML] Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction

L Ge, K Wang, H Lin, E Tao, W Xia, F Wang… - … in Bioengineering and …, 2023 - frontiersin.org
The tissue reconstruction of diabetic wounds mainly depends on the proliferation and
remodelling of cutaneous cells around wounds and the transplantation of random skin flaps …

Extracellular vesicles from HIF-1α-overexpressing adipose-derived stem cells restore diabetic wounds through accelerated fibroblast proliferation and migration

J Wang, H Wu, Y Zhao, Y Qin, Y Zhang… - International Journal …, 2021 - Taylor & Francis
Purpose Inhibition of cellular adaptation to hypoxia can cause persistent inflammation,
thereby increasing tissue damage and complicating wound healing in diabetes patients …

[HTML][HTML] Exosomes from adipose stem cells promote diabetic wound healing through the eHSP90/LRP1/AKT axis

S Ren, J Chen, J Guo, Y Liu, H Xiong, B Jing, X Yang… - Cells, 2022 - mdpi.com
Oxidative damage is a critical cause of diabetic wounds. Exosomes from various stem cells
could promote wound repair. Here, we investigated the potential mechanism by which …

[HTML][HTML] Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Accelerate Diabetic Wound Healing via Ameliorating Oxidative Stress and Promoting …

C Yan, Y Xv, Z Lin, Y Endo, H Xue, Y Hu… - … in bioengineering and …, 2022 - frontiersin.org
Diabetic wounds remain a great challenge for clinicians due to the multiple bacterial
infections and oxidative damage. Exosomes, as an appealing nanodrug delivery system …

Cell-free therapy based on adipose tissue stem cell-derived exosomes promotes wound healing via the PI3K/Akt signaling pathway

W Zhang, X Bai, B Zhao, Y Li, Y Zhang, Z Li… - Experimental cell …, 2018 - Elsevier
Introduction Adipose tissue-derived stem cells (ADSCs) have been shown to enhance
wound healing via their paracrine function. Exosomes, as one of the most important …

[HTML][HTML] Exosomes derived from adipose mesenchymal stem cells promote diabetic chronic wound healing through SIRT3/SOD2

Y Zhang, X Bai, K Shen, L Luo, M Zhao, C Xu, Y Jia… - Cells, 2022 - mdpi.com
Chronic wounds resulting from diabetes are a major health concern in both industrialized
and developing countries, representing one of the leading causes of disability and death …

Exosomes derived from human amniotic epithelial cells accelerate diabetic wound healing via PI3K-AKT-mTOR-mediated promotion in angiogenesis and fibroblast …

P Wei, C Zhong, X Yang, F Shu, S Xiao, T Gong… - Burns & …, 2020 - academic.oup.com
Background Diabetic wounds are one of the most common and serious complications of
diabetes mellitus, characterized by the dysfunction of wound-healing-related cells in quantity …

[HTML][HTML] ADSC-exo@ MMP-PEG smart hydrogel promotes diabetic wound healing by optimizing cellular functions and relieving oxidative stress

T Jiang, S Liu, Z Wu, Q Li, S Ren, J Chen, X Xu… - Materials Today Bio, 2022 - Elsevier
Diabetic wound complications are financially costly and difficult to heal in worldwide.
Whereas the therapies of diabetic wound, such as wound dressing, endocrine therapy or …