Platelets are central mediators of thrombosis and hemostasis. At the site of vascular injury,
platelet accumulation (ie adhesion and aggregation) constitutes the first wave of hemostasis …

Platelets have attracted a growing interest among basic scientists and clinicians, as they
have been shown to play an important role in many physiological and pathophysiological …

Thrombotic diseases such as heart attack and stroke remain a major health concern in the
Western world despite existing anti‐thrombotic drugs. Current studies are revealing structure …

Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …

Fibronectin is a component of subendothelial matrices and abundant in plasma. A role of
fibronectin in thrombogenesis has been suspected for three decades. Soluble fibronectin is …

Platelet adhesion is an essential function in response to vascular injury and is generally
viewed as the first step during which single platelets bind through specific membrane …

Circulating blood platelets attach to damaged blood vessels by specific adhesion molecules.
In the human arterial circulation, a unique'shear-dependent'mechanism governs adhesion …

Background: Recent studies have shown that platelet adhesion and subsequent
aggregation can occur in vivo in the absence of the two principal platelets adhesive ligands …

Arterial thrombosis is initiated after atherosclerotic plaque rupture. The ruptured plaque
triggers a cascade of platelet-mediated events that result in the formation of a platelet-rich …

At sites of vascular injury, platelets come into contact with the subendothelial extracellular
matrix which triggers their activation and the formation of a hemostatic plug. This process is …