The significance of mixed chimaerism and cell lineage chimaerism monitoring in paediatric patients post haematopoietic stem cell transplant

S Kricke, K Rao, S Adams - British Journal of Haematology, 2022 - Wiley Online Library
Haematopoietic stem cell transplants (HSCTs) are carried out across the world to treat
haematological and immunological diseases which would otherwise prove fatal. Certain …

Monitoring of chimerism following allogeneic haematopoietic stem cell transplantation (HSCT): technical recommendations for the use of short tandem repeat (STR) …

JR Clark, SD Scott, AL Jack, H Lee… - British journal of …, 2015 - Wiley Online Library
Analysis of short tandem repeats (STR) is the predominant method for post‐transplant
monitoring of donor engraftment. It can enable early detection of disease relapse, level of …

Quantification of chimerism within peripheral blood, bone marrow and purified leukocyte subsets: comparison of singleplex and multiplex PCR amplification of short …

O Beck, C Seidl, T Lehrnbecher… - European journal of …, 2006 - Wiley Online Library
Objective and Methods: Chimerism analysis has become a routine diagnostic procedure
after haematopoietic allogeneic stem cell transplantation for early detection of relapse of …

Important factors in implementation of lineage-specific chimerism analysis for routine use

TP Das, DA Kipp, DS Kliman, SS Patil… - Bone Marrow …, 2021 - nature.com
Monitoring of donor-specific chimerism is universally recognised as essential in the follow-
up of patients after allogeneic haemopoietic stem cell transplantation. Lineagespecific …

Validation of chimerism in pediatric recipients of allogeneic hematopoietic stem cell transplantation (HSCT) a comparison between two methods: real-time PCR (qPCR …

M Kletzel, W Huang, M Olszewski, S Khan - Chimerism, 2013 - Taylor & Francis
Post-hematopoietic stem cell transplantation (HSCT) chimerism monitoring is important to
assess relapse and therapeutic intervention. The purpose of our study is to compare two …

Highly-sensitive chimerism analysis in blood after allogeneic hematopoietic cell transplantation in childhood leukemia: Results from the Nordic Microchimerism Study

AK Haugaard, HO Madsen, TN Masmas… - Frontiers in …, 2023 - frontiersin.org
Analysis of chimerism in blood post‐HCT using STR‐PCR is routinely applied in parallel
with quantification of MRD to predict relapse of leukemia. Real time quantitative PCR (RQ …

Quantitative polymerase chain reaction technology in chimerism monitoring after hematopoietic stem cell transplantation: One center experience

K Stingl Jankovic, M Maskalan, M Burek Kamenaric… - HLA, 2019 - Wiley Online Library
Chimerism status evaluation is a routine test performed in post‐hematopoietic stem cell
transplantation (HSCT) period. The aim of the study was to evaluate a quantitative …

Progress in chimerism analysis in childhood malignancies–the dilemma of biostatistical considerations and ethical implications

T Klingebiel, D Niethammer, K Dietz, P Bader - Leukemia, 2001 - nature.com
In recent years, considerable progress has been made in the analysis of hematopoietic
chimerism after allogeneic stem cell transplantation (SCT). The introduction of serial and …

Chimerism monitoring techniques after hematopoietic stem cell transplantation: an overview of the last 15 years of innovations

P Tozzo, A Delicati, R Zambello, L Caenazzo - Diagnostics, 2021 - mdpi.com
Chimerism analysis is a well-established method for monitoring the state of hematopoietic
stem cell transplantation (HSCT) over time by analyzing peripheral blood or bone marrow …

Beyond chimerism analysis: methods for tracking a new generation of cell-based medicines

J Vives, A Casademont-Roca, L Martorell… - Bone Marrow …, 2020 - nature.com
The analysis of chimerism is crucial to determine the status of patients receiving
hematopoietic stem cell transplantation. The variety of relevant techniques available today …