Abstract Development of hyperbilirubinaemia is common in patients with advanced
pancreatic adenocarcinoma, both at diagnosis as well throughout disease evolution. For this …

In patients with advanced unresectable pancreatic cancer, the prognosis is generally poor.
Within recent years, new treatment options such as the FOLFIRINOX regimen (5-fluorouracil …

Introduction Treatment of patients with advanced pancreatic carcinoma (APC) and
hyperbilirubinaemia is problematic because these patients were regularly excluded from …

Purpose We assessed the impact of hepatic dysfunction on the safety and pharmacology of
gemcitabine/capecitabine in patients with advanced pancreatico-biliary cancer. Methods We …

Background: Do colorectal cancer patients with hyperbilirubinemia and liver metastases
benefit from chemotherapy? Methods/Results: This study entailed a review of 3,019 …

Background Von Hoff et al. demonstrated survival improvement with gemcitabine (GEM)+
nab-paclitaxel (NabP) for metastatic pancreatic ductal adenocarcinoma (PDAC) compared …

Background: Treatment of patients with severe liver dysfunction including hyperbilirubinemia
secondary to liver metastases of gastrointestinal (GI) cancer is challenging. Regimen of …

Cisplatin is the most effective and widely used anti-cancer drug for ovarian cancer. We
report 2 cases with severe hyperbilirubinemia after cisplatin-based chemotherapy. Case 1 …

• Prehepaticcausesoccurfrommassivebreakd…, producing bilirubin in such large quantities
that the liver is unable to keep up with its processing. Consequently, large amounts of …

At time of presentation the majority of patients with pancreaticobiliary cancer have locally
advanced or metastatic disease which makes them unamenable for curative surgery. In …