Significant variability of anticancer efficacy of dichloroacetate (DCA) stimulated an active
search for the agents capable to enhance it antitumor action. Therefore, the aim of this work …

Thiazolo [5, 4-b] quinolines are compounds structurally related to m-Amsacrine (m-Amsa), a
potent antileukemic drug that intercalates to DNA and inhibits topoisomerase II in vitro …

Acridine is a heterocyclic nucleus consisting of three fused rings heterocyclic moiety and a
presence of Nitrogen in the ring structure. It is used in a large number of therapeutically …

BACKGROUND OF THE INVENTION Throughout this application, various publications are
referenced. The disclosures of these publications in their entirety are hereby incorporated by …

One of the hallmarks of cancer cells is aerobic glycolysis (the Warburg effect). The effect of
dichloroacetate (DCA) is to switch glucose metabolism (cellular respiration) to a more …

An antitumor drug N-[2-(dimethylamino) ethyl] acridine-4-carboxamide (DACA) and its three
close structural analogs N-[2-(hydroxyethylamino) ethyl] acridine-4-carboxamide (DACAH) …

The article" Inhibition effects of acridone on the growth of breast cancer cells in vivo", by Y.-F.
Xia, H.-J. Chu, G.-F. Kuang, G.-J. Jiang, Y.-C. Che, published in Eur Rev Med Pharmacol Sci …

This paper describes extensive research on the activity of more of 100 cytotoxic compounds
containing an oxygenated ring in their structure and isolated from natural plants or prepared …

Topoisomerase II (TopoII) plays a critical role in the processes of replication, transcription,
and decantenation in the cell and is an important chemotherapeutic target in the treatment of …

This work aimed to investigate plasma pharmacokinetics and tissue distribution of a new
acridine derivative 5-acridin-9-ylmethylene-3-(4-methyl-benzyl)-thiazolidine-2, 4-dione …