The ability of the human kidney to repair itself is limited. Consequently, repeated injury can
trigger a maladaptive response that is characterized by fibrosis and loss of renal function …

The mammalian renal organ represents a pinnacle of complexity, housing functional filtering
units known as nephrons. During embryogenesis, the depletion of niches containing renal …

The mammalian kidney is a highly complex organ, composed of various cell types within a
unique structural framework. Nonetheless, in recent years, giant leaps in our understanding …

The adult kidney has a remarkable ability to survive injury and restore function despite a
limited turnover of cells under physiologic conditions. This accounts both for the tubular and …

Potential use of stem or progenitor cells for kidney regeneration | Nature Reviews Nephrology
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Human pluripotent cells are promising for treatment for kidney diseases, but the protocols for
derivation of kidney cell types are still controversial. Kidney tissue regeneration is well …

Kidney disease is a devastating condition that affects millions of people worldwide, and its
prevalence is predicted to significantly increase. The kidney is a complex organ …

Given its complexity, high metabolic activity and excretory functions, the kidney is particularly
susceptible to acute ischemic and toxin-mediated injury. Current therapies do not facilitate …

Human kidney is particularly susceptible to ischemia and toxins with consequential tubular
necrosis and activation of inflammatory processes. This process can lead to the acute renal …

While it remains unknown whether there is a stem cell in the adult kidney, characterization of
the cell populations involved in renal repair and misrepair is allowing a new understanding …