Digoxin is a cardiac glycoside and it is used for the treatment of supraventricular
tachycardia, atrial flutter, and re-entrant arrhythmias. Digoxin may be administered orally or …

The pharmacokinetic properties and dosage guidelines for digoxin in pediatric patients with
congestive heart failure are reviewed. Interindividual variability in the pharmacokinetics of …

Although digoxin is invaluable for a variety of cardiovascular diseases, and it is virtually the
only cardiac glycoside in common use today in children and infants, it is known to have a …

Pediatric Clinical Pharmacology of Digoxin Page 1 Symposium on Progress in Drug Therapy
for Children Pediatric Clinical Pharmacology of Digoxin Lester F. Soyka, MD* The purpose of …

The following summarises the contents of both this review and its predecessor in this journal
(Iisalo, 1977). The two reviews should be read in conjunction with each other. Digoxin is …

BACKGROUND: Because of its narrow therapeutic index, therapeutic monitoring of digoxin
is important in the management of infants and children receiving the drug for cardiac failure …

As a therapeutic principle, a disease should be treated with the lowest effective dose of a
drug. Accumulating information indicates that satisfactory contractile response of the …

Opinion about dosage of digoxin in paediatric patients is divided. Difficulties in assessing
the effect and toxicity of the glycoside in this age group could lead to administration of …

METHODS Twelve children, aged 2 months to 5.3 years (mean 30.4 months), were included
in the study (Table), after written parental consent and institutional ethical approval were …

The foregoing discussion leads to several general conclusions regarding the use of digoxin
in the pediatric patient. First, pharmacokinetic studies indicate that somewhat higher doses …