[HTML][HTML] SGK1. 1 limits brain damage after status epilepticus through M current-dependent and independent mechanisms

E Martin-Batista, LE Maglio, N Armas-Capote… - Neurobiology of …, 2021 - Elsevier
Epilepsy is a neurological condition associated to significant brain damage produced by
status epilepticus (SE) including neurodegeneration, gliosis and ectopic neurogenesis …

SGK1. 1 reduces kainic acid-induced seizure severity and leads to rapid termination of seizures

N Armas-Capote, LE Maglio, L Pérez-Atencio… - Cerebral …, 2020 - academic.oup.com
Approaches to control epilepsy, one of the most important idiopathic brain disorders, are of
great importance for public health. We have previously shown that in sympathetic neurons …

The neuronal serum-and glucocorticoid-regulated kinase 1.1 reduces neuronal excitability and protects against seizures through upregulation of the M-current

P Miranda, A Cadaveira-Mosquera… - Journal of …, 2013 - Soc Neuroscience
The M-current formed by tetramerization of Kv7. 2 and Kv7. 3 subunits is a neuronal voltage-
gated K+ conductance that controls resting membrane potential and cell excitability. In …

[HTML][HTML] Bi-directional genetic modulation of GSK-3β exacerbates hippocampal neuropathology in experimental status epilepticus

T Engel, R Gómez-Sintes, M Alves… - Cell death & …, 2018 - nature.com
Abstract Glycogen synthase kinase-3 (GSK-3) is ubiquitously expressed throughout the
brain and involved in vital molecular pathways such as cell survival and synaptic …

Up-regulation of serum-and glucocorticoid-induced protein kinase 1 in the brain tissue of human and experimental epilepsy

L Wang, C Zhou, Q Zhu, J Luo, Y Xu, Y Huang… - Neurochemistry …, 2010 - Elsevier
Several studies have shown that serum-and glucocorticoid-induced protein kinase 1 (SGK1)
can regulate both glutamate receptors and glutamate transporters and may participate in the …

Unraveling the Effects of GSK-3β Isoform Modulation against Limbic Seizures and in the 6 Hz Electrical Kindling Model for Epileptogenesis

N Aourz, F Van Leuven, W Allaoui… - ACS Chemical …, 2022 - ACS Publications
Two closely related glycogen synthase kinase-3 (GSK-3) isoforms have been identified in
mammals: GSK-3α and GSK-3β. GSK-3β is the most prominent in the central nervous …

Sgk1, a cell survival response in neurodegenerative diseases

B Schoenebeck, V Bader, XR Zhu, B Schmitz… - Molecular and Cellular …, 2005 - Elsevier
Serum and glucocorticoid-regulated kinase 1 (sgk1) belongs to a family of serine/threonine
kinases that is under acute transcriptional control by serum and glucocorticoids. An …

A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons

MF Arteaga, T Coric, C Straub… - Proceedings of the …, 2008 - National Acad Sciences
Neurodegenerative diseases and noxious stimuli to the brain enhance transcription of
serum-and glucocorticoid-induced kinase-1 (SGK1). Here, we report that the SGK1 gene …

Upregulation of serum and glucocorticoid-regulated kinase 1 exacerbates brain injury and neurological deficits after cardiac arrest

RHC Lee, MS Grames, CYC Wu… - American Journal …, 2020 - journals.physiology.org
Cardiopulmonary arrest (CA) is the leading cause of death and disability in the United
States. CA-induced brain injury is influenced by multifactorial processes, including reduced …

KCC2 activity is critical in limiting the onset and severity of status epilepticus

L Silayeva, TZ Deeb, RM Hines… - Proceedings of the …, 2015 - National Acad Sciences
The K+/Cl–cotransporter (KCC2) allows adult neurons to maintain low intracellular Cl–
levels, which are a prerequisite for efficient synaptic inhibition upon activation of γ …