Transgenic animal models of Alzheimer's disease (AD) are widely used to investigate
mechanisms of pathophysiology and cognitive dysfunctions. A model with a very early …

In the present report, we extend previous findings in the 5XFAD mouse model with regard to
a characterization of behavioral deficits and neuropathological alterations. We demonstrate …

Abstract 5XFAD is an early-onset mouse transgenic model of Alzheimer disease (AD). Up to
now there are no studies that focus on the epigenetic changes produced as a result of Aβ-42 …

In addition to memory impairments, patients with Alzheimer's disease (AD) exhibit a number
of behavioural and psychological symptoms that can affect social interactions over the …

The 5XFAD mice are an early‐onset transgenic model of Alzheimer's disease (AD) in which
amyloid plaques are first observed between two and four months of age in the cortical layer …

Background: The prevalence of Alzheimer's disease (AD) is greater in women compared to
men, but the reasons for this remain unknown. This sex difference has been widely …

The 5xFAD mouse model of Alzheimer's disease (AD) rapidly develops AD‐related neuro‐
behavioral pathology. Learning and memory impairments in 5xFAD mice, however, are not …

The frontal cortex is a brain structure that plays an important role in cognition and is known
to be affected in Alzheimer's disease (AD) in humans. Over the past years, transgenic mouse …

A promising direction in the research on Alzheimer's Disease (AD) is the identification of
biomarkers that better inform the disease progression of AD. However, the performance of …

Alzheimer's disease (AD) is characterized by distinct behavioral and cognitive deficits that
differ from those observed in normal aging. Transgenic models of AD are a promising tool in …