neuropathology of non‐tau frontotemporal lobar degeneration

M Neumann, IRA Mackenzie - Neuropathology and applied …, 2019 - Wiley Online Library
Frontotemporal dementia (FTD) is a heterogeneous clinical syndrome associated with
frontotemporal lobar degeneration (FTLD) as a relatively consistent neuropathological …

Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies

IRA Mackenzie, M Neumann - Journal of neurochemistry, 2016 - Wiley Online Library
Frontotemporal dementia (FTD) is a clinical syndrome with a heterogeneous molecular
basis. The past decade has seen the discovery of several new FTD‐causing genetic …

[HTML][HTML] Neuropathological background of phenotypical variability in frontotemporal dementia

KA Josephs, JR Hodges, JS Snowden… - Acta …, 2011 - Springer
Frontotemporal lobar degeneration (FTLD) is the umbrella term encompassing a
heterogeneous group of pathological disorders. With recent discoveries, the FTLDs have …

Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine

DJ Irwin, NJ Cairns, M Grossman, CT McMillan… - Acta …, 2015 - Springer
Frontotemporal lobar degeneration (FTLD) comprises two main classes of
neurodegenerative diseases characterized by neuronal/glial proteinaceous inclusions (ie …

Frontotemporal lobar degeneration: current concepts in the light of recent advances

S Kumar‐Singh, C Van Broeckhoven - Brain pathology, 2007 - Wiley Online Library
Work done over the past decade has led to a molecular understanding of frontotemporal
lobar degeneration (FTLD), a deadly disease that afflicts patients in mid‐life. It is a common …

[HTML][HTML] Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

IRA Mackenzie, M Neumann, EH Bigio, NJ Cairns… - Acta …, 2010 - Springer
One year ago, in this journal, we published a recommended nomenclature for the
neuropathologic subtypes of frontotemporal lobar degeneration (FTLD)[7]. A major impetus …

Frontotemporal lobar degeneration: epidemiology, pathology, diagnosis and management

RE Seltman, BR Matthews - CNS drugs, 2012 - Springer
Frontotemporal lobar degeneration (FTLD) describes a spectrum of clinically, pathologically
and genetically heterogeneous neurodegenerative disorders of unknown aetiology. FTLD …

Frontotemporal lobar degeneration

M Grossman, WW Seeley, AL Boxer, AE Hillis… - Nature Reviews …, 2023 - nature.com
Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset
dementia and presents with early social–emotional–behavioural and/or language changes …

Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects

G Halliday, EH Bigio, NJ Cairns, M Neumann… - Acta …, 2012 - Springer
Frontotemporal lobar degeneration (FTLD) is clinically, pathologically and genetically
heterogeneous. Three major proteins are implicated in its pathogenesis. About half of cases …

Neuroimaging in frontotemporal lobar degeneration—predicting molecular pathology

JL Whitwell, KA Josephs - Nature Reviews Neurology, 2012 - nature.com
Frontotemporal lobar degeneration (FTLD) encompasses a group of diseases characterized
by neuronal loss and gliosis of the frontal and temporal lobes. Almost all cases of FTLD can …