Aim Elevated basal endogenous glucose production (EGP), impaired suppression of EGP
by insulin and reduced insulin-stimulated glucose disposal are cornerstones of the …

OBJECTIVE—To determine the contribution of hepatic insulin resistance to the
pathogenesis of impaired fasting glucose (IFG). RESEARCH DESIGN AND METHODS …

Defects in hepatic insulin action in type 2 diabetes and its possible underlying mechanisms
were assessed in euglycemic-hyperinsulinemic clamp studies, using improved tracer …

Inasmuch as previous studies have obtained conflicting results on the contribution of obesity
to insulin resistance in noninsulin-dependent diabetes mellitus (NIDDM), we studied 10 …

Based on previous steady-state measures of the biologic activity of insulin, it was thought
that postprandial hyperinsulinemia in obesity compensated for insulin resistance. However …

To determine whether the hepatic insulin resistance of obesity and type 2 diabetes is due to
impaired insulin-induced suppression of glycogenolysis as well as gluconeogenesis, 10 …

We studied hepatic and extrahepatic insulin sensitivity and insulin release in seven
nonobese patients with mild noninsulin-dependent diabetes mellitus (NIDDM) and 10 …

To determine whether Impaired Glucose Tolerance gives rise to additional defects in insulin
action in lipid and ketone metabolism, thirty‐two obese subjects were studied by low‐dose …

Obesity is associated with impaired insulin action in glucose disposal, but not necessarily in
other aspects of intermediary metabolism or insulin clearance. Sixteen morbidly obese and …

Aim/hypothesis. To gain insight into the physiologic determinants of postabsorptive
endogenous glucose output (EGO) in humans.¶ Methods. We analysed the data of 344 non …