Deregulation of any of the steps in cell growth, proliferation and apoptosis may result in its
malignant transformation. Statins, along with their lipid-lowering potential, modify several …

In addition to a lipid-lowering effect, 3-hydroxy-3-methylglutaryl coenzyme A reductase
inhibitors (statins) have an effect on the expression levels of many genes. In order to …

Statins are widely prescribed and are established as first-line therapy for the primary and
secondary prevention of coronary artery disease. However, the benefit of treatment varies …

The relationship between statin use and cancer risk has been evaluated in numerous
observational studies and as a secondary outcome in randomized controlled trials …

Abstract The 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors
(statins) are among the most commonly prescribed drugs worldwide. On average, statins …

The significant age-adjusted decline in cardiovascular mortality that has occurred over the
past three decades is multifactorial. However, the advent of statin therapy has markedly …

Although all statin drugs lower levels of circulating low-density lipoprotein cholesterol by
inhibiting 3-hydroxy-3-methylglutaryl coenzyme A, molecular differences among statins …

Statins represent a major advance in the treatment of hypercholesterolemia, a significant risk
factor for atherosclerosis. There is, however, notable interindividual variation in the …

Genetic variability has been shown to affect statin responsiveness. Participants from the
Utrecht Cardiovascular Pharmacogenetics (UCP) studies were enrolled from a population …

Interindividual variability in response to 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase
inhibitors, or statins, with regard to both efficacy and safety is an obvious target for …