Harnessing regulatory T cells to establish immune tolerance
P Ho, E Cahir-McFarland, JD Fontenot… - Science Translational …, 2024 - science.org
Engineered regulatory T (Treg) cells have emerged as precision therapeutics aimed at
inducing immune tolerance while reducing the risks associated with generalized …
inducing immune tolerance while reducing the risks associated with generalized …
The therapeutic potential of regulatory T cells for the treatment of autoimmune disease
JA Bluestone, E Trotta, D Xu - Expert opinion on therapeutic targets, 2015 - Taylor & Francis
Introduction: Immune tolerance remains the holy grail of therapeutic immunology in the fields
of organ and tissue transplant rejection, autoimmune diseases, and allergy and asthma. We …
of organ and tissue transplant rejection, autoimmune diseases, and allergy and asthma. We …
[HTML][HTML] Engineered tolerance: tailoring development, function, and antigen-specificity of regulatory T cells
Regulatory T cells (Tregs) are potent suppressors of immune responses and are currently
being clinically tested for their potential to stop or control undesired immune responses in …
being clinically tested for their potential to stop or control undesired immune responses in …
Regulatory T cells: customizing for the clinic
X Wang, L Lu, S Jiang - Science translational medicine, 2011 - science.org
Immune-suppressive cellular immunotherapy requires large numbers of antigen-specific
regulatory T cells (Treg cells), lymphocytes that suppress certain immune responses …
regulatory T cells (Treg cells), lymphocytes that suppress certain immune responses …
[HTML][HTML] Super-Treg: toward a new era of adoptive Treg therapy enabled by genetic modifications
L Amini, J Greig, M Schmueck-Henneresse… - Frontiers in …, 2021 - frontiersin.org
Regulatory Tcells (Treg) are essential components of peripheral immune homeostasis.
Adoptive Treg cell therapy has shown efficacy in a variety of immune-mediated diseases in …
Adoptive Treg cell therapy has shown efficacy in a variety of immune-mediated diseases in …
Next-generation regulatory T cell therapy
Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …
[HTML][HTML] Therapeutic potential of gene-modified regulatory T cells: from bench to bedside
WJ Chae, ALM Bothwell - Frontiers in Immunology, 2018 - frontiersin.org
Regulatory T cells (Tregs) are an important subset of adaptive immune cells and control
immune reactions for maintaining homeostasis. Tregs are generated upon their encounter …
immune reactions for maintaining homeostasis. Tregs are generated upon their encounter …
Treg cell-based therapies: challenges and perspectives
C Raffin, LT Vo, JA Bluestone - Nature Reviews Immunology, 2020 - nature.com
Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …
[HTML][HTML] Regulatory T cells as immunotherapy
BD Singer, LS King, FR D'Alessio - Frontiers in immunology, 2014 - frontiersin.org
Regulatory T cells (Tregs) suppress exuberant immune system activation and promote
immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the …
immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the …
[HTML][HTML] Regulatory T cell-based therapies for autoimmunity
B Arellano, DJ Graber, CL Sentman - Discovery medicine, 2016 - ncbi.nlm.nih.gov
Autoimmune disorders are long-term diseases that adversely affect the quality of life for
patients, and they are one of the top ten leading causes of death. While each autoimmune …
patients, and they are one of the top ten leading causes of death. While each autoimmune …