Osteoporosis is an age-related, systemic skeletal disease that poses a significant public
health challenge in contemporary society. Development at the epigenetic level is emerging …

Bone marrow mesenchymal stem cells (BMSCs) nowadays are regarded as promising
candidates in cell‐based therapy for the regeneration of damaged bone tissues that are …

Altered DNA methylation upon ageing may result in many age‐related diseases such as
osteoporosis. However, the changes in DNA methylation that occur in cortical bones, the …

Insufficient activity of the bone-forming osteoblasts leads to low bone mass and predisposes
to fragility fractures. The functional capacity of human mesenchymal stem cells (hMSCs), the …

Disuse osteoporosis (DOP) is a common complication of the lack of mechanical loading. The
precise mechanism underlying DOP remains unknown, although epigenetic modifications …

Osteoporosis is a disease that impacts the elderly. Low estrogen is related to changes in
DNA methylation and consequent alterations in gene expression, leading to a new direction …

Bone tissue engineering may be hindered by underlying osteoporosis because of a
decreased osteogenic ability of autologous seed cells and an unfavorably changed …

The role and underlying mechanisms of DNA methylation in osteogenesis/chondrogenesis
remain poorly understood. We here reveal DNA methyltransferase 1 (DNMT1), which is …

Human bone marrow mesenchymal stem cells (MSCs) expanded in vitro exhibit not only a
tendency to lose their proliferative potential, homing ability and telomere length but also …

Osteoporosis is one of the most common metabolic skeletal diseases, which affects more
than 200 million people worldwide, especially elderly and postmenopausal women. One of …