The occurrence of atrial fibrillation (AF) is associated with progressive changes in the
calcium handling system of atrial myocytes. Calcium cycling instability has been implicated …

Atrial fibrillation (AF) is the most common cardiac arrhythmia, but our knowledge of the
arrhythmogenic substrate is incomplete. Alternans, the beat-to-beat alternation in the shape …

Atrial fibrillation (AF) alters atrial cardiomyocyte (ACM) Ca 2+ handling, promoting ectopic
beat formation. We examined the effects of AF-associated remodeling on Ca 2+-related …

Key points Cardiac alternans–periodic beat‐to‐beat alternations in contraction, action
potential (AP) morphology or cytosolic calcium transient (CaT) amplitude–is a high risk …

Alternans is a risk factor for cardiac arrhythmia, including atrial fibrillation. At the cellular
level alternans is observed as beat-to-beat alternations in contraction, action potential (AP) …

Key points Cardiac alternans refers to a beat‐to‐beat alternation in contraction, action
potential (AP) morphology and Ca2+ transient (CaT) amplitude, and represents a risk factor …

Heart failure (HF) is associated with an increased propensity for atrial fibrillation (AF),
causing higher mortality than AF or HF alone. It is hypothesized that HF-induced remodelling …

Cardiac calcium alternans is defined as beat-to-beat alternations of Ca transient (CaT)
amplitude and has been linked to cardiac arrhythmia, including atrial fibrillation. We …

Action potential duration (APD) alternans (APD-ALT), defined as beat-to-beat oscillations in
APD, has been proposed as an important clinical marker for chronic atrial fibrillation (cAF) …

Cardiac electrical alternans (CEA), manifested as T-wave alternans in ECG, is a clinical
biomarker for predicting cardiac arrhythmias and sudden death. However, the mechanism …