The beat-to-beat alternation in action potential durations (APDs) in the heart, called APD
alternans, has been linked to the development of serious cardiac rhythm disorders, including …

Alternans of cardiac repolarization is associated with arrhythmias and sudden death. At the
cellular level, alternans involves beat-to-beat oscillation of the action potential (AP) and …

Arrhythmogenic action potential alternans (APD-ALT) is thought to arise from beat to beat
alteration in cellular Ca2+ cycling. Previously, we found that spatial heterogeneity in APD …

Atrial calcium transient (CaT) alternans is defined as beat-to-beat alternations in CaT
amplitude and is causally linked to atrial fibrillation (AF). Mitochondria play a significant role …

Optical mapping of intact cardiac tissue reveals that, in some cases, intracellular calcium
(Ca) release can alternate from one beat to the next in a large-small-large sequence, also …

Alternans, a condition in which there is a beat-to-beat alternation in the electromechanical
response of a periodically stimulated cardiac cell, has been linked to the genesis of life …

Electrocardiographic alternans, a phenomenon of beat-to-beat alternation in cardiac
electrical waveforms, has been implicated in the pathogenesis of ventricular arrhythmias …

Electro-mechanical and Ca alternans is a beat-to-beat alternation of action potential
duration, contraction strength and Ca transient amplitude observed in cardiac myocytes at …

Aims Atrial fibrillation (AF) is increased in patients with heart failure resulting from
myocardial infarction (MI). We aimed to determine the effects of chronic ventricular MI in …

ECG alternans is commonly held to be an indicator of electrical instability of the heart, but
the development of alternans has not yet been fully understood theoretically. We investigate …