BACKGROUND: Although heart failure (HF) is closely associated with susceptibility to
sudden cardiac death (SCD), the mechanisms linking contractile dysfunction to cardiac …

Atrial fibrillation (AF) remains a major clinical problem (Nattel et al., 2021). Conceptually, AF
requires a trigger, often in the form of ectopic (triggered) activity, and a vulnerable substrate …

Beat-to-beat alternation in the cardiac intracellular Ca (Ca i) transient can drive action
potential (AP) duration alternans, creating a highly arrhythmogenic substrate. Although a …

Atrial fibrillation is the most common arrhythmia, yet treatment strategies are sub-optimal due
to incomplete understanding of the underlying mechanisms. Spatio-temporal sub-cellular …

In heart failure (HF), T-tubule (TT) disruption contributes to dyssynchronous calcium (Ca)
release and impaired contraction, but its role in arrhythmogenesis remains unclear. In this …

Although alternans of action potential duration (APD) is a robust feature of the rapidly paced
canine ventricle, currently available ionic models of cardiac myocytes do not recreate this …

Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon
where different regions of cardiac tissue exhibit an alternating sequence of APD that are out …

The dynamics of many cardiac arrhythmias, as well as the nature of transitions between
different heart rhythms, have long been considered evidence of nonlinear phenomena …

By sensing changes in intracellular Ca 2+, small-conductance Ca 2+-activated K+(SK)
channels dynamically regulate the dynamics of the cardiac action potential (AP) on a beat-to …

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and its prevalence is
increasing with the ageing of the population. Presently available treatment options are far …