Objective Reversible/irreversible abnormalities of regional cerebral blood flow (rCBF) are
seen in patients with depression. However, in late‐life depression there is little evidence of a …

Background The neurobiological mechanisms of depression are increasingly being
explored through resting-state brain imaging studies. However, resting-state fMRI findings …

Background. Hypofrontality has been demonstrated in mood disorders by functional brain
imaging methods such as positron emission tomography. However, the neurobiological …

Background Despite the known relationship between prefrontal function and increased
suicidality during major depressive episodes, the links between prefrontal function and …

Several studies have suggested that there is frontal dysfunction in subjects with
posttraumatic stress disorder (PTSD). We investigated the relationship between alterations …

Background A functional discrepancy exists in adolescents between frontal and subcortical
regions due to differential regional maturational trajectories. It remains unknown how this …

Prefrontal left-right functional imbalance and disrupted prefronto-thalamic circuitry are
plausible mechanisms for treatment-resistant depression (TRD). Add-on repetitive …

BACKGROUND: Executive deficits associated with frontal lobe dysfunction are prominent in
depression. We applied a newly developed WM task to investigate the neural correlates of …

The prefrontal cortex, a part of the limbic-thalamic-cortical network, participates in regulation
of mood, cognition and behavior and has been implicated in the pathophysiology of major …

Introduction Although depression is commonly accompanied by cognitive deficits, the
underlying mechanism remains unclear. One possibility is that such deficits are related to …