Acute respiratory virus infection (ARI) induces CD8+ T cells with diminished cytokine
production and functional impairment. The role of cellular mediators of immune impairment …

The lung is an important line of defense that is exposed to respiratory infectious pathogens,
including viruses. Lung epithelial cells and/or alveolar macrophages are initially targeted by …

Viral acute respiratory infections (ARIs) are associated with cluster of differentiation (CD) 8+
T cells that exhibit diminished production of cytokines and cytotoxic molecules. Though …

ABSTRACT Foxp3+ CD4+ regulatory T cells (Tregs) represent a highly suppressive T cell
subset with well-characterized immunosuppressive effects during immune homeostasis and …

Abstract Regulatory Foxp3+ CD4 T cells (Tregs) prevent spontaneous inflammation in the
lungs, inhibit allergic and asthmatic responses, and contribute to tolerance to inhaled …

Regulatory T cells (Tregs) play a crucial and complex role in balancing the immune
response to viral infection. Primarily, they serve to regulate the immune response by limiting …

Viral lung infections are leading causes of morbidity and mortality. Effective immune
responses to these infections require precise immune regulation to preserve lung function …

Regulatory CD4+ T cells have been shown to be important in limiting immune responses,
but their role in respiratory viral infections has received little attention. Here we observed that …

During viral infection, inflammation and recovery are tightly controlled by competing
proinflammatory and regulatory immune pathways. Respiratory syncytial virus (RSV) is the …

In addition to regulating autoimmunity and antitumor immunity, CD4+ CD25+ FoxP3+ natural
regulatory T (Treg) cells are global regulators of adaptive immune responses. Depletion of …