Mechanisms mediating the impact of maternal obesity on offspring hypothalamic development and later function

IC Furigo, L Dearden - Frontiers in endocrinology, 2022 - frontiersin.org
As obesity rates have risen around the world, so to have pregnancies complicated by
maternal obesity. Obesity during pregnancy is not only associated with negative health …

[HTML][HTML] Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways

L Dearden, S Buller, IC Furigo… - Molecular …, 2020 - Elsevier
Objective Perinatal exposure to maternal obesity results in predisposition of offspring to
develop obesity later in life. Increased weight gain in offspring exposed to maternal obesity …

Early life influences on obesity risk: maternal overnutrition and programming of obesity

MJ Morris - Expert Review of Endocrinology & Metabolism, 2009 - Taylor & Francis
While adult lifestyle factors undoubtedly contribute to the incidence of obesity and its
attendant disorders, mounting evidence suggests that programming of obesity may occur …

Female and male C57BL/6J offspring exposed to maternal obesogenic diet develop altered hypothalamic energy metabolism in adulthood

D Kulhanek, JE Abrahante Llorens… - American Journal …, 2022 - journals.physiology.org
Maternal obesity is exceedingly common and strongly linked to offspring obesity and
metabolic disease. Hypothalamic function is critical to obesity development. Hypothalamic …

Emerging role of hypothalamus in the metabolic regulation in the offspring of maternal obesity

J Zhang, S Li, X Luo, C Zhang - Frontiers in Nutrition, 2023 - frontiersin.org
Maternal obesity has a significant impact on the metabolism of offspring both in childhood
and adulthood. The metabolic regulation of offspring is influenced by the intrauterine …

Effects of neonatal programming on hypothalamic mechanisms controlling energy balance

C Contreras, MG Novelle, R Leis… - Hormone and …, 2013 - thieme-connect.com
The prevalence of overweight and obesity in most developed countries has markedly
increased during the last decades. In addition to genetic, hormonal, and metabolic …

Persistent influence of maternal obesity on offspring health: Mechanisms from animal models and clinical studies

UD Wankhade, KM Thakali, K Shankar - Molecular and cellular …, 2016 - Elsevier
The consequences of excessive maternal weight and adiposity at conception for the
offspring are now well recognized. Maternal obesity increases the risk of overweight and …

Maternal obesity: lifelong metabolic outcomes for offspring from poor developmental trajectories during the perinatal period

E Zambrano, C Ibáñez, PM Martinez-Samayoa… - Archives of medical …, 2016 - Elsevier
The prevalence of obesity in women of reproductive age is increasing in developed and
developing countries around the world. Human and animal studies indicate that maternal …

The Endocrine–Metabolic Axis Regulation in Offspring Exposed to Maternal Obesity—Cause or Consequence in Metabolic Disease Programming?

LF Grilo, MS Diniz, C Tocantins, AL Areia, SP Pereira - Obesities, 2022 - mdpi.com
Obesity incidence is rising worldwide, including women of reproductive age, contributing to
increased gestations in which Maternal Obesity (MO) occurs. Offspring born to obese …

Neurodevelopmental programming of adiposity: contributions to obesity risk

AA Skowronski, RL Leibel, CA LeDuc - Endocrine Reviews, 2024 - academic.oup.com
This review analyzes the published evidence regarding maternal factors that influence the
developmental programming of long-term adiposity in humans and animals via the central …