Recent studies have resulted in deeper understanding of a variety of telomere maintenance
mechanisms as well as plausible models of telomere evolution. Often overlooked in the …

It has been known for decades that telomerase extends the 3′ end of linear eukaryotic
chromosomes and dictates the telomeric repeat sequence based on the template in its RNA …

Telomere maintenance is essential for the genome integrity of eukaryotes, and this function
is underpinned by the two-step telomeric DNA synthesis process: telomere G-overhang …

CST is both an ssDNA-binding complex and a DNA Pol-α/primase cofactor that coordinates
the switch from G-strand elongation to C-strand fill-in during telomere maintenance. Four …

A 3′ overhang is critical for the protection and maintenance of mammalian telomeres, but
its synthesis must be regulated to avoid excessive resection of the 5′ end, which could …

Coats plus (CP) is a rare autosomal recessive disorder caused by mutations in CTC 1, a
component of the CST (CTC 1, STN 1, and TEN 1) complex important for telomere length …

Recent advances in our structural understanding of telomerase and telomere-associated
proteins have contributed significantly to elucidating the molecular mechanisms of telomere …

Mammalian telomeric DNA contains duplex TTAGGG repeats and single-stranded
overhangs. POT1 (protection of telomeres 1) is a telomere-specific single-stranded DNA …

Telomeres ensure chromosome length homeostasis and protection from catastrophic end-to-
end chromosome fusions. All eukaryotes require this essential, strictly conserved telomere …

Most eukaryotes stabilize the ends of their linear chromosomes with a telomerase-based
system. Telomerase maintains specific repetitive sequences, which protect chromosome …