Telomeric DNA at eukaryotic chromosome ends terminates with single stranded 3′ G-rich
overhangs. The overhang is generated by the interplay of several dynamic processes …

Human chromosome end-capping and telomerase regulation require POT1 (Protection of
Telomeres 1) and TPP1 proteins, which bind to the 3′ ssDNA extension of human …

Abstract CST (CTC1-STN1-TEN1) is a telomere associated complex that binds ssDNA and
is required for multiple steps in telomere replication, including termination of G-strand …

Bacteria and viruses possess circular DNA, whereas eukaryotes with typically very large
DNA molecules have had to evolve into linear chromosomes to circumvent the problem of …

Deleting the OB folds encoding the telomeric single-stranded DNA (ssDNA)-binding activity
of the human telomeric protein POT1 induces significant telomere elongation, suggesting …

Telomeres are unique nucleoprotein structures. Found at the edge of each chromosome,
their main purpose is to mask DNA ends from the DNA-repair machinery by formation of …

Work in model organisms, such as mouse, yeast, Tetrahymena, ciliates, and plants, has led
to a deeper understanding of telomere biology. Telomeres together with telomere-binding …

The linearity of chromosomes creates two major problems for eukaryotic cells: the end-
replication problem and the endprotection problem. The end-replication problem stems from …

Telomerase adds simple-sequence repeats to the ends of linear chromosomes to counteract
the loss of end sequence inherent in conventional DNA replication. Catalytic activity for …

Yet another protein has been added to the crowd of players found at the ends of
chromosomes. Known variously as PTOP, PIP1 or TINT1, this negative regulator of telomere …