To maintain linear DNA genomes, organisms have evolved numerous means of solving
problems associated with DNA ends (telomeres), including telomere-associated …

How a cell deals with its DNA ends is a question that returns us to the very beginnings of
modern telomere biology. It is also a question we are still asking today because it is …

Telomerase contributes to chromosome end replication by synthesizing repeats of telomeric
DNA, and the telomeric DNA‐binding proteins protection of telomeres (POT1) and TPP1 …

Telomeres are specialized nucleoprotein complexes that provide protection to the ends of
eukaryotic chromosomes. Telomeric DNA consists of tandemly repeated G-rich sequences …

The regulation of telomere length in mammals is crucial for chromosome end-capping and
thus for maintaining genome stability and cellular lifespan. This process requires …

Telomeres are protein–DNA complexes that protect chromosome ends from illicit ligation
and resection. Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA to …

Most human cells lack telomerase, the enzyme that elongates telomeres. The resulting
telomere erosion eventually limits cell proliferation and tissue renewal, thereby impacting …

Telomerase recruitment to telomeres and enzymatic processivity are mediated by TPP1, an
essential component of telomere integrity and telomerase function. A surface on the OB …

To prevent progressive telomere shortening as a result of conventional DNA replication, new
telomeric DNA must be added onto the chromosome end. The de novo DNA synthesis …

Genome organization into linear chromosomes likely represents an important evolutionary
innovation that has permitted the development of the sexual life cycle; this process has …