[HTML][HTML] Telomere protection by TPP1/POT1 requires tethering to TIN2
KK Takai, T Kibe, JR Donigian, D Frescas, T De Lange - Molecular cell, 2011 - cell.com
To prevent ATR activation, telomeres deploy the single-stranded DNA binding activity of
TPP1/POT1a. POT1a blocks the binding of RPA to telomeres, suggesting that ATR is …
TPP1/POT1a. POT1a blocks the binding of RPA to telomeres, suggesting that ATR is …
Finding the end: recruitment of telomerase to telomeres
J Nandakumar, TR Cech - Nature reviews Molecular cell biology, 2013 - nature.com
Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …
Telomerase unplugged
G Cristofari, K Sikora, J Lingner - ACS chemical biology, 2007 - ACS Publications
The control of telomerase activity at chromosome ends by telomere-binding proteins is
critical for telomere length homeostasis. Two recent papers identify TPP1 as a critical …
critical for telomere length homeostasis. Two recent papers identify TPP1 as a critical …
Telomere dynamics in mammals
DC Silvestre, A Londoño-Vallejo - Repetitive DNA, 2012 - karger.com
Telomeres are specialized structures found at the end of linear chromosomes. Telomere
structure and functions are conserved throughout evolution and are essential for genome …
structure and functions are conserved throughout evolution and are essential for genome …
Telomerase biogenesis: The long road before getting to the end
F Gallardo, P Chartrand - RNA biology, 2008 - Taylor & Francis
Telomere maintenance in eukaryotes is linked to cellular proliferation capacity. The
telomerase holoenzyme, which maintains telomere length, is a central actor in this process …
telomerase holoenzyme, which maintains telomere length, is a central actor in this process …
CST–polymerase α-primase solves a second telomere end-replication problem
H Takai, V Aria, P Borges, JTP Yeeles, T de Lange - Nature, 2024 - nature.com
Telomerase adds G-rich telomeric repeats to the 3′ ends of telomeres, counteracting
telomere shortening caused by loss of telomeric 3′ overhangs during leading-strand DNA …
telomere shortening caused by loss of telomeric 3′ overhangs during leading-strand DNA …
[HTML][HTML] Zipper head mechanism of telomere synthesis by human telomerase
F Wan, Y Ding, Y Zhang, Z Wu, S Li, L Yang, X Yan… - Cell research, 2021 - nature.com
Telomerase, a multi-subunit ribonucleoprotein complex, is a unique reverse transcriptase
that catalyzes the processive addition of a repeat sequence to extend the telomere end …
that catalyzes the processive addition of a repeat sequence to extend the telomere end …
Telomere and telomerase biology
Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special
structures that cap chromosome ends to prevent degradation by nucleolytic attack and to …
structures that cap chromosome ends to prevent degradation by nucleolytic attack and to …
Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1
Telomeres are nucleoprotein complexes comprising telomeric DNA repeats bound by the
multiprotein shelterin complex. A dynamic binary switch between telomerase-extendible and …
multiprotein shelterin complex. A dynamic binary switch between telomerase-extendible and …
The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance
JH Teichroeb, J Kim, DH Betts - RNA biology, 2016 - Taylor & Francis
Telomeres are linear guanine-rich DNA structures at the ends of chromosomes. The length
of telomeric DNA is actively regulated by a number of mechanisms in highly proliferative …
of telomeric DNA is actively regulated by a number of mechanisms in highly proliferative …