To prevent ATR activation, telomeres deploy the single-stranded DNA binding activity of
TPP1/POT1a. POT1a blocks the binding of RPA to telomeres, suggesting that ATR is …

Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …

The control of telomerase activity at chromosome ends by telomere-binding proteins is
critical for telomere length homeostasis. Two recent papers identify TPP1 as a critical …

Telomeres are specialized structures found at the end of linear chromosomes. Telomere
structure and functions are conserved throughout evolution and are essential for genome …

Telomere maintenance in eukaryotes is linked to cellular proliferation capacity. The
telomerase holoenzyme, which maintains telomere length, is a central actor in this process …

Telomerase adds G-rich telomeric repeats to the 3′ ends of telomeres, counteracting
telomere shortening caused by loss of telomeric 3′ overhangs during leading-strand DNA …

Telomerase, a multi-subunit ribonucleoprotein complex, is a unique reverse transcriptase
that catalyzes the processive addition of a repeat sequence to extend the telomere end …

Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special
structures that cap chromosome ends to prevent degradation by nucleolytic attack and to …

Telomeres are nucleoprotein complexes comprising telomeric DNA repeats bound by the
multiprotein shelterin complex. A dynamic binary switch between telomerase-extendible and …

Telomeres are linear guanine-rich DNA structures at the ends of chromosomes. The length
of telomeric DNA is actively regulated by a number of mechanisms in highly proliferative …