Undruggable targets typically refer to a class of therapeutic targets that are difficult to target
through conventional methods or have not yet been targeted, but are of great clinical …

The development and application of traditional drugs represented by small molecule
chemical drugs and biological agents, especially inhibitors, have become the mainstream …

Targeted protein degradation is becoming a weapon of choice against targets considered
heretofore “undruggable.” Whereas most small molecules inhibit a protein by blocking its …

Traditional drug discovery mainly focuses on direct regulation of protein activity. The
development and application of protein activity modulators, particularly inhibitors, has been …

Recent advances in small-molecule mediated protein degradation have fueled interest in
applying such technology to drug development. Whereas conventional therapeutics require …

The targeted protein degradation (TPD) field has expanded rapidly since the first PROTACs
were reported, enabling the development of novel therapeutics for a range of targets …

Abstract Targeted Protein degraders (TPDs) show promise in harnessing cellular machinery
to eliminate disease-causing proteins, even those previously considered undruggable …

The therapeutic strategy of targeted protein degradation (TPD) has undergone a massive
growth in interest over the last several years. Founded in 2015, C4 Therapeutics was one of …

The discovery and development of targeted protein degraders have become important areas
of research in the field of medicinal chemistry. Inducing degradation of a target protein …

The chemical understanding of biological processes provides not only a deeper insight but
also a solution to abnormal biological functioning. Protein degradation, a natural biological …