Positively charged amino acid residues in the extracellular loops A and C of lens aquaporin 0 interact with the negative charges in the plasma membrane to facilitate …
S Kumari, G Taginik, S Varadaraj, K Varadaraj - Experimental eye research, 2019 - Elsevier
This investigation was undertaken to find out whether the positive charges in the
Extracellular Loops A (ELA) and C (ELC) of Aquaporin 0 (AQP0) are involved in lens fiber …
Extracellular Loops A (ELA) and C (ELC) of Aquaporin 0 (AQP0) are involved in lens fiber …
Molecular mechanism of Aquaporin 0-induced fiber cell to fiber cell adhesion in the eye lens
K Varadaraj, SS Kumari - Biochemical and biophysical research …, 2018 - Elsevier
Cell-to-cell adhesion (CTCA), which is key for establishing lens transparency, is a critical
function of Aquaporin 0 (AQP0). The aim of this investigation was to find out the possible …
function of Aquaporin 0 (AQP0). The aim of this investigation was to find out the possible …
The extracellular C-loop domain plays an important role in the cell adhesion function of aquaporin 0
Y Nakazawa, M Oka, M Funakoshi-Tago… - Current Eye …, 2017 - Taylor & Francis
ABSTRACT Purpose: Although aquaporin 0 (AQP0) is a member of the AQP family, it has
limited water permeability compared with other members. AQP0 may also have cell …
limited water permeability compared with other members. AQP0 may also have cell …
A predominant form of C-terminally end-cleaved AQP0 functions as an open water channel and an adhesion protein in AQP0ΔC/ΔC mouse lens
SS Kumari, K Varadaraj - Biochemical and biophysical research …, 2019 - Elsevier
The purpose of this investigation was to find out whether C-terminally end-cleaved
aquaporin 0 (AQP0), that is present predominantly in the lens mature fiber cells of the WT …
aquaporin 0 (AQP0), that is present predominantly in the lens mature fiber cells of the WT …
Intact AQP0 performs cell-to-cell adhesion
SS Kumari, K Varadaraj - Biochemical and biophysical research …, 2009 - Elsevier
Aquaporins (AQPs) constitute a major conduit for movement of water across plasma
membranes. AQP0 is expressed in the fiber cells and is critical for lens transparency and …
membranes. AQP0 is expressed in the fiber cells and is critical for lens transparency and …
Differences in a single extracellular residue underlie adhesive functions of two zebrafish Aqp0s
I Vorontsova, JE Hall, TF Schilling, N Nagai… - Cells, 2021 - mdpi.com
Aquaporin 0 (AQP0) is the most abundant lens membrane protein, and loss of function in
human and animal models leads to cataract formation. AQP0 has several functions in the …
human and animal models leads to cataract formation. AQP0 has several functions in the …
[HTML][HTML] Unique and analogous functions of aquaporin 0 for fiber cell architecture and ocular lens transparency
SS Kumari, S Eswaramoorthy, RT Mathias… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Aquaporin (AQP) 1 and AQP0 water channels are expressed in lens epithelial and fiber
cells, respectively, facilitating fluid circulation for nourishing the avascular lens to maintain …
cells, respectively, facilitating fluid circulation for nourishing the avascular lens to maintain …
Functional characterization of an AQP0 missense mutation, R33C, that causes dominant congenital lens cataract, reveals impaired cell-to-cell adhesion
SS Kumari, J Gandhi, MH Mustehsan, S Eren… - Experimental eye …, 2013 - Elsevier
Abstract Aquaporin 0 (AQP0) performs dual functions in the lens fiber cells, as a water pore
and as a cell-to-cell adhesion molecule. Mutations in AQP0 cause severe lens cataract in …
and as a cell-to-cell adhesion molecule. Mutations in AQP0 cause severe lens cataract in …
Verification and spatial localization of aquaporin-5 in the ocular lens
AC Grey, KL Walker, RS Petrova, J Han… - Experimental eye …, 2013 - Elsevier
Until recently, the lens was thought to express only two aquaporin (AQP) water channels,
AQP1 and AQP0. In this study we confirm lenticular AQP5 protein expression by Western …
AQP1 and AQP0. In this study we confirm lenticular AQP5 protein expression by Western …
Intact and N-or C-terminal end truncated AQP0 function as open water channels and cell-to-cell adhesion proteins: end truncation could be a prelude for adjusting the …
SS Kumari, K Varadaraj - Biochimica et Biophysica Acta (BBA)-General …, 2014 - Elsevier
Background Investigate the impact of natural N-or C-terminal post-translational truncations
of lens mature fiber cell Aquaporin 0 (AQP0) on water permeability (Pw) and cell-to-cell …
of lens mature fiber cell Aquaporin 0 (AQP0) on water permeability (Pw) and cell-to-cell …