Group I metabotropic glutamate receptor‐mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking
HD Schmidt, BA Kimmey, AC Arreola… - Addiction …, 2015 - Wiley Online Library
Emerging evidence indicates that type I metabotropic glutamate receptors (mGluRs) in the
nucleus accumbens play a critical role in cocaine seeking. The present study sought to …
nucleus accumbens play a critical role in cocaine seeking. The present study sought to …
Stimulation of mGluR5 in the accumbens shell promotes cocaine seeking by activating PKC gamma
HD Schmidt, RL Schassburger, LA Guercio… - Journal of …, 2013 - Soc Neuroscience
Recent studies indicate a critical role for metabotropic glutamate receptor 5 (mGluR5) in the
reinstatement of cocaine seeking. However, the signal transduction pathways through which …
reinstatement of cocaine seeking. However, the signal transduction pathways through which …
Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming-and cue-induced reinstatement of cocaine seeking
V Kumaresan, M Yuan, J Yee, KR Famous… - Behavioural brain …, 2009 - Elsevier
Accumulating evidence suggests that metabotropic glutamate receptors (mGluRs) are
involved in both cocaine reinforcement and the reinstatement of cocaine-seeking behavior …
involved in both cocaine reinforcement and the reinstatement of cocaine-seeking behavior …
Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the nucleus accumbens of cocaine-treated rats
DA Mitrano, C Arnold, Y Smith - Neuroscience, 2008 - Elsevier
There is significant pharmacological and behavioral evidence that group I metabotropic
glutamate receptors (mGluR1a and mGluR5) in the nucleus accumbens play an important …
glutamate receptors (mGluR1a and mGluR5) in the nucleus accumbens play an important …
mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism
Abstract Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-
administration and reinstatement of drug-seeking behavior. However, the cellular and …
administration and reinstatement of drug-seeking behavior. However, the cellular and …
Using metabotropic glutamate receptors to modulate cocaine's synaptic and behavioral effects: mGluR1 finds a niche
Group I metabotropic glutamate receptors (mGluR) are important modulators of excitatory
synaptic transmission and therefore potential targets for drug development. In several brain …
synaptic transmission and therefore potential targets for drug development. In several brain …
Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine
Repeated cocaine produces enduring neuroadaptations in glutamate transmission in the
nucleus accumbens that are thought to contribute to addiction. Group II metabotropic …
nucleus accumbens that are thought to contribute to addiction. Group II metabotropic …
The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine-and food-seeking behavior in rats
J Peters, PW Kalivas - Psychopharmacology, 2006 - Springer
Rationale Group II metabotropic glutamate receptor (mGluR2/3) agonists are proposed to
serve as potential treatment for addiction. Objectives The present study examined the …
serve as potential treatment for addiction. Objectives The present study examined the …
Activation of mGluR7s inhibits cocaine‐induced reinstatement of drug‐seeking behavior by a nucleus accumbens glutamate‐mGluR2/3 mechanism in rats
X Li, J Li, EL Gardner, ZX Xi - Journal of neurochemistry, 2010 - Wiley Online Library
J. Neurochem.(2010) 114, 1368–1380. Abstract The metabotropic glutamate receptor 7
(mGluR7) has been reported to be involved in cocaine and alcohol self‐administration …
(mGluR7) has been reported to be involved in cocaine and alcohol self‐administration …
Long-Lasting Impairment of mGluR5-Activated Intracellular Pathways in the Striatum After Withdrawal of Cocaine Self-Administration
HM Hoffmann, N Crouzin, E Moreno… - International Journal …, 2017 - academic.oup.com
Background: Cocaine addiction continues to be a major heath concern, and despite public
health intervention there is a lack of efficient pharmacological treatment options. A newly …
health intervention there is a lack of efficient pharmacological treatment options. A newly …