In the field of nanotherapeutics, gaining cellular entry into the cytoplasm of the target cell
continues to be an ultimate challenge. There are many physicochemical factors such as …

Cell‐penetrating peptides (CPPs) can transport various cargoes through membranes of live
cells. Since the first generations of CPPs suffered from insufficient cell and tissue selectivity …

The selective infiltration of cell membranes and tissue barriers often blocks the entry of most
active molecules. This natural defense mechanism prevents the invasion of exogenous …

The complex physiological and pathological conditions form barriers against efficient drug
delivery. Cell penetrating peptides (CPPs), a class of short peptides which translocate drugs …

The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …

In today's modern era of medicine, macromolecular compounds such as proteins, peptides
and nucleic acids are dethroning small molecules as leading therapeutics. Given their …

ABSTRACT Introduction: Cell penetrating peptides (CPPs) known as protein translocation
domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able …

Efficient intracellular drug delivery and target specificity are often hampered by the presence
of biological barriers. Thus, compounds that efficiently cross cell membranes are the key to …

Efficient delivery of therapeutic and diagnostic molecules to the cells and tissues is a difficult
challenge. The cellular membrane is very effective in its role as a selectively permeable …

The selective permeability of the plasma membrane prohibits most exogenous agents from
gaining cellular access. Since many therapeutics and reporter molecules must be …