The recent discovery of new potent therapeutic molecules which do not reach the clinic due
to poor delivery and low bioavailability have made the delivery of molecules a keystone in …

The demand for highly efficient macromolecular drugs, used in the treatment of many severe
diseases, is continuously increasing. However, the hydrophilic character and large …

Cell-penetrating peptides (CPPs) have been previously shown to be powerful transport
vector tools for the intracellular delivery of a large variety of cargoes through the cell …

The process of introducing drugs into cells has always proved a major challenge for
research scientists and for the pharmaceutical industry. The cell membrane is selectively …

Abstract Cell-penetrating peptides (CPPs), often vividly termed as the “Trojan Horse”
peptides, have attracted considerable interest for the intracellular delivery of a wide range of …

Cancer has become one of the leading causes of mortality globally. The major challenges of
conventional cancer therapy are the failure of most chemotherapeutic agents to accumulate …

Despite continuing advances in the development of biomacromolecules for therapeutic
purposes, successful application of these often large and hydrophilic molecules has been …

One of the major challenges for new therapeutics molecules to enter the clinic remains
improving their bioavailability and cellular uptake. Therefore, delivery has become a key …

Cell-penetrating peptides (CPPs) have been discovered to deliver chemical drugs, nucleic
acids, and macromolecules to permeate cell membranes, creating a novel route for …

Unique characteristics, such as nontoxicity and rapid cellular internalization, allow the cell-
penetrating peptides (CPPs) to transport hydrophilic macromolecules into cells, thus …