The ability to translocate the cellular membranes and gain access to the cell interior,
including the different cellular compartments, still remains a major obstacle in current drug …

Biophysical studies have a very high impact on the understanding of internalization,
molecular mechanisms, interactions, and localization of CPPs and CPP/cargo conjugates in …

The presence of cell and tissue barriers together with the low biomembrane permeability of
various therapeutics often hampers systemic drug distribution; thus, most of the available …

Abstract Cell-penetrating peptides (CPPs), also known as protein transduction domains, are
a class of diverse peptides with 5‑30 amino acids. CPPs are divided into cationic …

During the last decade, cell-penetrating peptides have been investigated for their ability to
overcome the plasma membrane barrier of mammalian cells for the intracellular or …

During the last decade, small peptides (10 to 15 amino acids) derived from the HIV-1 Tat
protein and from the drosophila Antennapedia homeodomain have been used to internalize …

Despite continuing advances in the development of macromolecules, including peptides,
proteins, and oligonucleotides, for therapeutic purposes, the successful application of these …

Cell‐penetrating peptides (CPPs) have become widely used vectors for the cellular import of
molecules in basic and applied biomedical research. Despite the broad acceptance of these …

The clinical use of efficient therapeutic agents is often limited by the poor permeability of the
biological membranes. In order to enhance their cell delivery, short amphipathic peptides …

Delivering drug molecules into the cell is one of the major challenges in the process of drug
development. In past, cell penetrating peptides have been successfully used for delivering a …