The blood-brain barrier (BBB), a dynamic and complex barrier formed by endothelial cells,
can impede the entry of unwanted substances–pathogens and therapeutic molecules alike …

Cell-penetrating peptides (CPPs) are a growing family of peptides that have opened a new
avenue in drug delivery, allowing various hydrophilic macromolecules to enter cells. In …

Conspectus One of the recent hot topics in peptide-related chemical biology research is the
potential of cell-penetrating peptides (CPPs). Owing to their ability to deliver exogenous …

The cell membrane poses a substantial hurdle to the use of pharmacologically active
biomacromolecules that are not per se actively translocated into cells. An appealing …

During the past few decades, the novel biotherapeutic agents such as peptides and proteins
have been contributed to the treatment of several diseases. However, their oral absorption is …

Cell-penetrating peptides (CPPs) have recently gained considerable interest due to their
ability to cross cellular membranes and deliver macromolecular cargo. It is of great …

Twenty years ago, the discovery of peptides able to cross cellular membranes launched a
novel field in molecular delivery based on these non-invasive vectors, most commonly …

Extensive research has been undertaken in the pursuit of anticancer therapeutics. Many
anticancer drugs require specificity of delivery to cancer cells, whilst sparing healthy tissue …

Extensive research efforts have been made and are still ongoing in the search for an ideal
anti-cancer therapy. Almost all chemotherapeutics require a carrier or vehicle, a drug …

Efficient intracellular trafficking and targeted delivery to the site of action are essential to
overcome the current drawbacks of cancer therapeutics. Cell Penetrating Peptides (CPPs) …