[HTML][HTML] Corticotropin-releasing hormone exerts direct effects on neuronal progenitor cells: implications for neuroprotection

Y Koutmani, PK Politis, M Elkouris, G Agrogiannis… - Molecular …, 2013 - nature.com
Neurogenesis during embryonic and adult life is tightly regulated by a network of
transcriptional, growth and hormonal factors. Emerging evidence indicates that activation of …

[HTML][HTML] Impact of glucocorticoid on neurogenesis

H Odaka, N Adachi, T Numakawa - Neural regeneration research, 2017 - journals.lww.com
Neurogenesis is currently an area of great interest in neuroscience. It is closely linked to
brain diseases, including mental disorders and neurodevelopmental disease. Both …

[HTML][HTML] Actions of brain-derived neurotrophic factor and glucocorticoid stress in neurogenesis

T Numakawa, H Odaka, N Adachi - International journal of molecular …, 2017 - mdpi.com
Altered neurogenesis is suggested to be involved in the onset of brain diseases, including
mental disorders and neurodegenerative diseases. Neurotrophic factors are well known for …

Glucocorticoid receptor down-regulation affects neural stem cell proliferation and hippocampal neurogenesis

S Kim, S Yang, J Kim, KW Chung, YS Jung… - Molecular …, 2024 - Springer
Dysregulation of the hypothalamic–pituitary–adrenal axis and abnormalities in the
glucocorticoid receptor (GR) have been linked to major depressive disorder. Given the …

[HTML][HTML] Stress, glucocorticoid receptors, and adult neurogenesis: a balance between excitation and inhibition?

DJ Saaltink, E Vreugdenhil - Cellular and Molecular Life Sciences, 2014 - Springer
Adult neurogenesis, the birth of new neurons in the mature brain, has attracted considerable
attention in the last decade. One of the earliest identified and most profound factors that …

Corticotropin-releasing hormone (CRH) downregulates the function of its receptor (CRF1) and induces CRF1 expression in hippocampal and cortical regions of the …

KL Brunson, DE Grigoriadis, MT Lorang… - Experimental neurology, 2002 - Elsevier
In addition to regulating the neuroendocrine stress response, corticotropin-releasing
hormone (CRH) has been implicated in both normal and pathological behavioral and …

Differential disinhibition of the neonatal hypothalamic–pituitary–adrenal axis in brain‐specific CRH receptor 1‐knockout mice

MV Schmidt, JM Deussing, MS Oitzl… - European Journal of …, 2006 - Wiley Online Library
In the adult, corticotropin‐releasing hormone (CRH) is the key mediator for the behavioural
and neuroendocrine response to stress. It has also been hypothesized that, during postnatal …

The CRHR1/CREB/REST signaling cascade regulates mammalian embryonic neural stem cell properties

M Kwon, JH Lee, Y Yoon, SJ Pleasure, K Yoon - EMBO reports, 2023 - embopress.org
Growing evidence suggests that the corticotropin‐releasing hormone (CRH) signaling
pathway, mainly known as a critical initiator of humoral stress responses, has a role in …

[HTML][HTML] Impact of maternal deprivation on brain corticotropin-releasing hormone circuits: prevention of CRH receptor-2 mRNA changes by desipramine treatment

DM Vázquez, R Eskandari, A Phelka… - …, 2003 - nature.com
Corticotropin-releasing hormone (CRH) acts within the brain and pituitary to coordinate the
overall endocrinological and behavioral stress response. From postnatal day (PND) 4 to 14 …

Chronic glucocorticoid exposure suppressed the differentiation and survival of embryonic neural stem/progenitor cells: Possible involvement of ERK and PI3K/Akt …

H Odaka, T Numakawa, A Yoshimura, S Nakajima… - Neuroscience …, 2016 - Elsevier
Growing evidence suggests that excess glucocorticoids (GCs) exposure during the
pregnancy results in behavioral abnormality in offspring. Although research using animal …