Prenatal malnutrition could promote renal dysfunction in adulthood, but it is unclear whether
the detrimental effect could be transmitted to the next generation. We investigated whether …

Objective Chronic kidney disease (CKD) is an increasing contributor to the global disease
burden. Previous findings indicated that exposure to famine in early life was associated with …

Background and objectives Famine exposure in human early life is proven to be associated
with urinary protein concentration and renal function but has not been studied with chronic …

Background The impact of an adverse prenatal environment such as famine exposure on
the development of adulthood non-communicable chronic illnesses, including diabetes and …

Background: Animal models have suggested that undernutrition during gestation and the
early postnatal period may adversely affect kidney development and compromise renal …

Objective To evaluate the association of early-life exposure to the Chinese Great Famine
(1959–1961) with DNA methylation in IGF2 and its subsequent influence on blood lipid …

Famine exposure during early life development can affect disease risk in late-life period, yet,
transmission of phenotypic features from famine-exposed individuals to the next generations …

Background Early-life developmental adaptations in response to severe malnutrition may
play a crucial role in susceptibility to hypertension. This study aimed to explore the …

Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation
(DNAm), underlie the relationship between adverse intrauterine conditions and adult …

Abstract The Developmental Origins of Health and Disease theory suggests that early-life
malnutrition is associated with an increased risk of chronic disease in adulthood. In this …