Prostate and breast cancer are the two cancers with the highest incidence in men and
women, respectively. Here, we focus on the known biology of acquired resistance to …

The combined incidence and the extended disease course of breast and prostate cancer is
a major challenge for health care systems. The solution for society requires an economically …

Prostate and breast cancer are the two cancers with the highest incidence in men and
women, respectively. Here, we focus on the known biology of acquired resistance to …

Publisher Summary The breast and prostate cancer belong to the spectrum of hormone-
related malignancies. So, this chapter seeks to review current knowledge about the role of …

Breast and prostate cancer are the most well-characterized cancers of the type that have
their development and growth controlled by the endocrine system. These cancers are the …

Simple Summary Biochemical inhibition of male sex hormone function (androgen signaling),
also known as androgen deprivation therapy (ADT), for human prostate cancer remains a …

Prostate carcinoma is the most frequently diagnosed malignancy and the second leading
cause of death as a result of cancer in men in the western countries. Withdrawal of …

Over 60 years ago Huggins and Hodges demonstrated the importance of androgens and
prostate cancer. Since then, significant research has revealed that this relationship is multi …

Castration resistance is in part attributable to aberrant activation of androgen receptor (AR)
signaling by the intracrine activation of androgen precursors derived from adrenal glands …

Prostate epithelium growth and differentiation depend on androgens. Any manipulation that
reduces the level of testosterone will rapidly initiate apoptotic cell death in normal epithelia …