Background: PTPN22 plays a crucial role in regulating the function of various cells of the
immune system, particularly T cells. Polymorphisms of the PTPN22 gene have been …

Abstract Background Type 1 diabetes (T1D) is a T-cell mediated autoimmune multifactorial
disease. The PTPN22 gene encodes an intracellular lymphoid-specific phosphatase (Lyp) …

The protein tyrosine phosphatase nonreceptor 22 gene (PTPN22) is an important negative
regulator of signal transduction through the T-cell receptors (TCR). Recently a single …

Background: Recent investigations have reported an association between protein tyrosine
phosphatase non-receptor type-22 (PTPN-22) gene polymorphism and susceptibility to the …

The 1858T variant of the protein tyrosine phosphatase gene, PTPN22, is associated with an
increased risk of several autoimmune diseases. The aim of this study has been to …

OBJECTIVE—The minor allele of the nonsynonymous single nucleotide polymorphism
(SNP)+ 1858C> T within the PTPN22 gene is positively associated with type 1 diabetes and …

Background Type 1 diabetes mellitus (T1D) is a T cell-mediated autoimmune disease
characterized by the destruction of pancreatic β cells. PTPN22 and IL2RA polymorphisms …

It is known that the etiology and clinical outcomes of autoimmune diseases are associated
with a combination of genetic and environmental factors. In the case of the genetic factor, the …

Objective Type 1 diabetes, a multigenic autoimmune disorder, is caused by the destruction
of pancreatic beta-cells leads to insufficient insulin production and hyperglycemia, resulting …

Background: Single-nucleotide polymorphism (SNP) rs2476601 within protein tyrosine
phosphatase non-receptor type 22 gene (PTPN22) has been shown to be a risk factor for …