In the current investigation, 5-epi-incensole (3) and 5-epi-incensole acetate (5) were
synthesized from the most potent anti-depressant constituents incensole (1) and incensole …

In the course of our continuing exploration for novel bioactive lead compounds (s) from the
species Boswellia, we have recently reported incensole derivatives isolated from Boswellia …

Encouraged by the potent anti-depression activities of incensole (1) and incensole acetate
(2) isolated from the resin of Boswellia papyrifera in our previous work, different derivatives …

Incensole acetate (IA), a constituent of Boswellia resin ('frankincense'), was previously
demonstrated to exhibit an antidepressive-like effect in the Forced Swim Test (FST) in mice …

Silymarin, a plant-derived polyphenolic flavonoid of Silybum marianum, elicited significant
antidepressant-like activity in an acute restraint stress model of depression. It improved …

Neuroinflammation has emerged as an important factor in the molecular underpinnings of
major depressive disorder (MDD) pathophysiology and in the mechanism of action of …

Introduction: Although drugs currently available for the treatment of anxiety and depression
act through modulation of the neurotransmission systems involved in the neurobiology of the …

We have earlier reported antidepressant-like effect of Cnestis ferruginea and its bioflavonoid
constituent, amentoflavone in behavioural paradigms but its effects on neurochemical and …

Background Chronic unpredictable stressors can produce a situation similar to human
depression and such animal models can be used for the preclinical evaluation of …

Objectives The inconsistent therapeutic outcome necessitates identifying novel compounds
for the treatment of depression. Therefore, the present study is aimed at evaluating the …