The importance of phosphate control in chronic kidney disease

K Tsuchiya, T Akihisa - Nutrients, 2021 - mdpi.com
A series of problems including osteopathy, abnormal serum data, and vascular calcification
associated with chronic kidney disease (CKD) are now collectively called CKD-mineral bone …

Osteo‐renal regulation of systemic phosphate metabolism

MS Razzaque - IUBMB life, 2011 - Wiley Online Library
Impaired kidney function and subsequent skeletal responses play a critical role in disrupting
phosphate balance in chronic kidney disease (CKD) patients with mineral and bone …

FGF23-αKlotho as a paradigm for a kidney-bone network

M Kuro-o, OW Moe - Bone, 2017 - Elsevier
The vertebrate endoskeleton is not a mere frame for muscle attachment to facilitate
locomotion, but is a massive organ integrated with many physiologic functions including …

The challenge of controlling phosphorus in chronic kidney disease

JB Cannata-Andía, KJ Martin - Nephrology Dialysis …, 2016 - academic.oup.com
The pathogenesis and management of chronic kidney disease-mineral bone disorders
(CKD-MBD) has experienced major changes, but the control of serum phosphorus at all …

Overview of the FGF23-Klotho axis

M Kuro-o - Pediatric nephrology, 2010 - Springer
Recent studies have identified a novel bone− kidney endocrine axis that maintains
phosphate homeostasis. When phosphate is in excess, fibroblast growth factor-23 (FGF23) …

[HTML][HTML] Phosphate balance and CKD–mineral bone disease

SM Sprague, KJ Martin, DW Coyne - Kidney International Reports, 2021 - Elsevier
Chronic kidney disease mineral bone disorder (CKD-MBD) is a common co-morbidity in
patients with CKD. Characterized by laboratory abnormalities, bone abnormality, and …

The roles of the skeleton and phosphorus in the CKD mineral bone disorder

KA Hruska, S Mathew - Advances in chronic kidney disease, 2011 - Elsevier
The CKD mineral bone disorder is a new term coined to describe the multiorgan system
failure that is a major component of the excess cardiovascular mortality and morbidity …

Hyperphosphatemia and chronic kidney disease: a major daily concern both in adults and in children

J Bacchetta, J Bernardor, C Garnier, C Naud… - Calcified tissue …, 2021 - Springer
Hyperphosphatemia is common in chronic kidney disease (CKD). Often seen as the “silent
killer” because of its dramatic effect on vascular calcifications, hyperphosphatemia explains …

Phosphate and FGF23 in early CKD: on how to tackle an invisible foe

M Ketteler, AT Petermann - Nephrology Dialysis Transplantation, 2011 - academic.oup.com
In the development of 'chronic kidney disease–mineral bone disorder'(CKD–MBD), the
current discussion ranks around the phrase 'which comes first'[1, 2]: calcitriol deficiency …

New insights into the FGF23-Klotho axis

H Olauson, MG Vervloet, M Cozzolino, ZA Massy… - Seminars in …, 2014 - Elsevier
Abnormal mineral metabolism is a hallmark in patients with advanced chronic kidney
disease (CKD). Hyperphosphatemia, and the homeostatic mechanisms controlling …