Increasing evidence indicates that the NOD-like receptors (NLRs) family may act as critical
back-up defenses and provide synergistic responses when confronted with persistent …

Cytosolic NOD-like receptors (NLRs) have been associated with human diseases including
infections, cancer, and autoimmune and inflammatory disorders. These innate immune …

Innate immunity comprises several inflammation-related modulatory pathways which receive
signals from an array of membrane-bound and cytoplasmic pattern recognition receptors …

Background Recently, many studies have reported that some botanicals and natural
products were able to regulate NOD-like receptor signaling. NOD-like receptors (NLRs) …

NOD-like receptor (NLR) proteins are intracellular innate immune sensors/receptors that
regulate immunity. This work shows that NLRX1 serves as a tumor suppressor in colitis …

NOD-like receptor protein 3 (NLRP3) may contribute to the growth and propagation of breast
cancer (BC). The effect of estrogen receptor-α (ER-α), progesterone receptor (PR), and …

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. The
incidence of HCC is strikingly higher in males than in females. The remarkable gender …

Nucleotide-binding and oligomerization structural domain (NOD)-like receptors (NLRs) play
an important role in innate immunity as cytoplasmic pattern recognition receptors (PRRs) …

Cellular homeostasis in higher organisms is maintained by balancing cell growth,
differentiation, and death. Two important systems that transmit extracellular signals into the …

NLRP6, a member of the Nod-like receptor family, protects against chemically induced
intestinal injury and colitis-associated colon cancer. However, the cellular mechanisms …