Abstract pH responsive cisplatin prodrug crosslinked polysaccharide-based nanoparticles
were developed from succinic acid decorated dextran (Dex-SA) for active loading and …

Carboplatin is a platinum based drug used in the treatment of several malignancies. Due to
poor cellular uptake, generally, a larger dose of drug is administered to achieve therapeutic …

Benznidazole is a promising antitumor drug because it has the ability to induce the
production of intracellular reactive oxygen species. In this study, poly (d, l-lactide-co …

Chemotherapy is the first choice for the treatment of cancer but it is still limited by insufficient
kill efficiency and drug resistance. These problems urgently need to be overcome in a way …

Background Platinum-based chemotherapy in non-small cell lung cancer (NSCLC) has
been demonstrated as a promising approach by many researchers. However, due to low …

Platinum-based combination therapy is more effective and less toxic, but lack of targeting,
and is not capable to enrich in the tumor zone. To obstacle these drawbacks, prodrug and …

Poly (alkyl cyanoacrylates) with a higher alkyl chain length is relatively less toxic than those
with a lower alkyl chain length. Several interesting studies were reported on the usefulness …

Background and Aim Polymeric nanoparticles (NPs) have received much attention as
promising carrier systems in lung cancer and brain metastases. Methods Here, for the first …

Background Although cisplatin is extensively used in the clinical field, its intrinsic toxicity
limits its clinical use. We investigated nanoparticle formations of poly (acrylic acid-co-methyl …

This study developed polymeric nanoparticles (NPs) conjugated with monoclonal antibody
(mAb) for glioblastoma treatment. In this study, the physicochemical properties of poly (butyl …