Most coagulase-negative staphylococcal species, including the opportunistic pathogen
Staphylococcus epidermidis, struggle to maintain redox homeostasis and grow under …

Intracellular pathogens must resist the antimicrobial actions of nitric oxide (NO·) produced by
host cells. To this end pathogens possess several NO·-metabolizing enzymes. Here we …

Escherichia coli flavohaemoglobin (Hmp) is the best-understood nitric oxide (NO)
detoxifying protein and exhibits a robust dioxygenase activity, converting NO to nitrate ion …

Microbial flavohaemoglobins are proteins with homology to haemoglobins from higher
organisms, but clearly linked to nitric oxide (NO) metabolism by bacteria and yeast. hmp …

Nitric oxide (NO) biology has focused on the tightly regulated enzymatic mechanism that
transforms l-arginine into a family of molecules, which serve both signaling and defense …

In microorganisms, flavohemoglobins (FHbs) containing FAD and heme (Fe 3+, metHb)
convert NO. into nitrate at the expense of NADH and O 2. FHbs contribute to bacterial …

Nitric oxide (NO) is an inevitable product of life in an oxygen-and nitrogen-rich environment.
This reactive diatomic molecule exhibits microbial cytotoxicity, in large part by facilitating …

Staphylococcus aureus is one of the most successful human pathogens, colonizing 2 billion
individuals worldwide and causing invasive infections even in immunocompetent hosts. S …

Escherichia coli possesses a flavohemoglobin (Hmp), product of hmp, the first microbial
globin gene to be sequenced and characterized at the molecular level. Although related …

Flavohemoglobins (FlavoHb) play a key role in bacterial resistance to nitrosative stress and
NO signaling modulation. In this study, we cloned, expressed, and characterized the flavoHb …