Stem/progenitor cells are involved in the regeneration of the renal tubules after damage due
to a toxic insult. However, the mechanism involved in the regeneration of the tubules by the …

The proximal tubules of the kidney are target sites of injury by various toxicants. Cadmium
(Cd+ 2), an environmental nephrotoxicant can cause adverse effects and overt renal …

Cadmium represents a major environmental pollutant that may induce severe damage,
especially in the kidney where cadmium accumulates. While cadmium is known to severely …

Cadmium is a well-studied environmental pollutant where the kidney and particularly the
proximal tubule cells are especially sensitive as they are exposed to higher concentrations …

Numerous studies showed that renal proximal tubules cells are the cell type critically
affected by chronic exposure to cadmium (Cd2+). The aim of the present study was to apply …

Eleven separate isolates of human renal proximal tubule cells (HPT) were analyzed for toxic
response to ionic cadmium exposure over a 16-day period in vitro. This study demonstrates …

Cadmium toxicity to renal cells was investigated in Madin-Darby canine kidney (MDCK) and
LLC-PK1 cells as models of the distal tubule/collecting duct and proximal tubule …

Cadmium (Cd) is a known nephrotoxic element. In this study, the primary cultures of rat
proximal tubular (rPT) cells were treated with low doses of cadmium acetate (2.5 and 5 µM) …

Abstract Cadmium (Cd 2+) is a known nephrotoxin causing tubular necrosis during acute
exposure and potentially contributing to renal failure in chronic long-term exposure. To …

Enzymes of the cytochrome P450 (CYP) super-family are implicated in cadmium (Cd)−
induced nephrotoxicity, however, direct evidence is lacking. This study investigated the …