Simple Summary To produce the proteins needed for the cell to survive, the information in
the DNA is converted to a mobile form known as messenger RNA, which exits the cell …

The 5′ mRNA cap structure is essential for efficient gene expression from yeast to human. It
plays a critical role in all aspects of the life cycle of an mRNA molecule. Capping occurs co …

Translational control is an important strategy by which eukaryotic cells regulate gene
expression. Translation is the last step in the flow of genetic information, and regulation at …

In mammals, cap-dependent translation of mRNAs is initiated by two distinct mechanisms:
cap-binding complex (CBC; a heterodimer of CBP80 and 20)-dependent translation (CT) …

The cap structure that is characteristic of all polymerase‐II‐transcribed RNAs has been
shown to play an important role in many aspects of RNA metabolism including RNA …

It has long been considered that intron-containing (spliced) mRNAs are translationally more
active than intronless mRNAs (identical mRNA not produced by splicing). The splicing …

Cancer cells depend on cap-dependent translation more than normal tissue. This explains
the emergence of proteins involved in the cap-dependent translation as targets for potential …

Eukaryotic mRNAs contain a 5′ cap structure that is crucial for recruitment of the translation
machinery and initiation of protein synthesis. mRNA recognition is thought to require direct …

In eukaryotes, the m7GpppN cap structure is added to all nascent RNA polymerase II
transcripts, and serves important functions at multiple steps of RNA metabolism. The …

Methyl-7-guanosine (m7G)“capping” of coding and some noncoding RNAs is critical for their
maturation and subsequent activity. Here, we discovered that eukaryotic translation initiation …