Natural killer cells and T cells in hepatocellular carcinoma and viral hepatitis: current status and perspectives for future immunotherapeutic approaches

SG Kalathil, Y Thanavala - Cells, 2021 - mdpi.com
Natural killer (NK) cells account for 25–50% of the total number of hepatic lymphocytes,
which implicates that NK cells play an important role in liver immunity. The frequencies of …

Natural killer cell responses in hepatocellular carcinoma: implications for novel immunotherapeutic approaches

S Mantovani, B Oliviero, S Varchetta, D Mele… - Cancers, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) still represents a significant complication of chronic liver
disease, particularly when cirrhosis ensues. Current treatment options include surgery, loco …

Natural killer cells in liver disease and hepatocellular carcinoma and the NK cell‐based immunotherapy

P Liu, L Chen, H Zhang - Journal of Immunology Research, 2018 - Wiley Online Library
Nature killer (NK) cells play a critical role in host innate and adaptive immune defense
against viral infections and tumors. NK cells are enriched in liver hematopoietic cells with …

The dynamic role of NK cells in liver cancers: role in HCC and HBV associated HCC and its therapeutic implications

M Sajid, L Liu, C Sun - Frontiers in Immunology, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) remains an important complication of chronic liver disease,
especially when cirrhosis occurs. Existing treatment strategies include surgery, loco-regional …

Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic approaches

M Yu, Z Li - Frontiers of Medicine, 2017 - Springer
Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third
leading cause of cancer-related mortalities worldwide. In the last few years, treatments for …

Natural killer cells in liver disease

V Male, KA Stegmann, NJ Easom… - Seminars in Liver …, 2017 - thieme-connect.com
Natural killer (NK) cells comprise one of the most abundant immune cell populations in
human liver and the nature and functions of these cells have been a focus of recent interest …

Impact of natural killer cells on chronic hepatitis C and hepatocellular carcinoma

T Tatsumi, T Takehara - Hepatology Research, 2016 - Wiley Online Library
Natural killer (NK) cells are involved in the pathogenesis of hepatitis C viral (HCV) infection
and hepatocellular carcinoma (HCC). Recent immunological progresses have revealed the …

Natural killer cells and regulatory T cells cross talk in hepatocellular carcinoma: exploring therapeutic options for the next decade

AG Bozward, F Warricker, YH Oo… - Frontiers in …, 2021 - frontiersin.org
Despite major advances in immunotherapy, hepatocellular carcinoma (HCC) remains a
challenging target. Natural Killer (NK) cells are crucial components of the anti-HCC immune …

[PDF][PDF] Natural killer cells in liver disease

Z Tian, Y Chen, B Gao - Hepatology, 2013 - Wiley Online Library
Natural killer (NK) cells are enriched in lymphocytes within the liver and have unique
phenotypic features and functional properties, including tumor necrosis factor–related …

Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy

C Sun, H Sun, W Xiao, C Zhang, Z Tian - Acta Pharmacologica Sinica, 2015 - nature.com
The mechanisms linking hepatitis B virus (HBV) and hepatitis C virus (HCV) infection to
hepatocellular carcinoma (HCC) remain largely unknown. Natural killer (NK) cells account …