Aging coincides with a higher frequency of muscle disuse and recovery events (due to
illness, surgery, pain) that are likely to lead to rapid loss of muscle mass and strength. Full …

Impaired recovery of aged muscle following a disuse event is an unresolved issue facing the
older adult population. Although investigations in young animals have suggested that rapid …

Skeletal muscle injury in aged rodents is characterized by an asynchronous infiltration of pro-
and anti-inflammatory macrophage waves, leading to improper and incomplete …

Macrophages are involved in skeletal muscle repair through pro-inflammatory and
alternative functions. We tested the hypothesis that aging alters the abundance and …

The regenerative potential of skeletal muscle, and overall muscle mass, decline with age.
This regenerative potential may be influenced by autocrine growth factors intrinsic to the …

Chang-Yi Cui and Luigi Ferrucci www. aging-us. com 3 AGING subtypes, Lyve1loMHCIIhi
and Lyve1hiMHCIIlo, were shown to express several M1 and M2 markers, respectively …

Poor recovery of muscle size and strength with aging coincides with a dysregulated
macrophage response during the early stages of regrowth. Immunomodulation in the form of …

The aging of multicellular organisms is characterized by structural and functional changes at
all levels, ranging from the molecular to the organismal. These changes are generally …

Age-related muscle weakening may ultimately result in the transition from an independent to
a dependent life-style. The decline in muscle strength is larger than expected from the loss …

The world's elderly population is expanding rapidly, and we are now faced with the
significant challenge of maintaining or improving physical activity, independence, and …