In Saccharomyces cerevisiae, RIF1 negatively regulates telomere length, but the
mechanism of this regulation remains unclear. We sought to elucidate Rif1 telomere length …

In budding yeast, Rif1 negatively regulates telomere length, but the mechanism of this
regulation has remained elusive. Previous work identified several functional domains of …

The Rif1 protein negatively regulates telomeric TG repeat length in the budding yeast
Saccharomyces cerevisiae, but how it prevents telomere over-extension is unknown. Rif1 …

To examine the established link between DNA replication and telomere length, we tested
whether firing of telomeric origins would cause telomere lengthening. We found that RIF1 …

The Saccharomyces cerevisiae telomere-binding protein Rif1 plays an evolutionarily
conserved role in control of DNA replication timing by promoting PP1-dependent …

Telomeres, the ends of eukaryotic chromosomes, consist of repetitive DNA sequences and
their bound proteins that protect the end from the DNA damage response. Short telomeres …

Chromosomal DNA replication involves the coordinated activity of hundreds to thousands of
replication origins. Individual replication origins are subject to epigenetic regulation of their …

The Rif1 protein, originally identified as a telomere-binding factor in yeast, has recently been
implicated in DNA replication control from yeast to metazoans. Here, we show that budding …

In yeast, Rif1 is part of the telosome, where it inhibits telomerase and checkpoint signaling at
chromosome ends. In mammalian cells, Rif1 is not telomeric, but it suppresses DNA end …

One of the long-standing questions in eukaryotic DNA replication is the mechanisms that
determine where and when a particular segment of the genome is replicated. Cdc7/Hsk1 is …