In addition to regulating renal sodium resorption and, thus, intravascular volume,
aldosterone may have direct effects on the cardiovascular system. We previously identified a …

In addition to regulating renal sodium resorption and, thus, intravascular volume,
aldosterone may have direct effects on the cardiovascular system. We previously identified a …

Background Aldosterone has essential roles in regulating intravascular volume and blood
pressure, and is suggested to influence cardiac structure. However, the association of …

Altered control of aldosterone synthase (CYP11B2) gene expression may modulate
aldosterone secretion, as suggested by a raised aldosterone to renin ratio (ARR) in some …

Background A single-nucleotide polymorphism in the aldosterone synthase gene
(CYP11B2) promoter [− 344C/T, rs1799998] has been reported to associate with …

Abstract The C (− 344) T promoter polymorphism of the human aldosterone synthase
(CYP11B2) gene has been associated with hypertension and cardiac hypertrophy, but there …

Background—Aldosterone has direct and indirect effects on the heart, and genetic variations
in aldosterone synthesis could therefore influence cardiac structure and function. Such …

Several polymorphisms in genes of the renin-angiotensin-aldosterone system have been
found to have pleiotropic effects on cardiovascular disorders. Recently, a polymorphism …

The role of aldosterone for the regulation of blood pressure, although recognized for many
years, has recently gained increasing attention. Primary abnormalities of aldosterone, in …

Background—The− 344C allele of a 2-allele (C or T) polymorphism in the promoter of the
gene encoding aldosterone synthase (CYP11B2) is associated with increased left …