Polymorphisms affecting the synthesis of aldosterone or its regulation may have effects on
blood pressure. For example, an autosomal dominant form of human hypertension …

Background Aldosterone is an important cardiovascular hormone; 15% of hypertensive
subjects have alteration in aldosterone regulation, defined by a raised ratio of aldosterone to …

Objectives: The aim of our study was to evaluate the relationship between aldosterone
synthase gene polymorphism and cardiac dimensions in essential hypertension …

A common polymorphism exists for the aldosterone synthase (CYP11B2) gene at position
344 (C-344-T). The 344-C allele has been associated with increased aldosterone synthase …

There have been few epidemiological studies on the gene-environmental interaction
between the aldosterone synthase gene (CYP11B2) T− 344C polymorphism and sodium in …

Several frequent polymorphisms in the CYP11B2 gene are suggested to be associated with
essential hypertension and aldosterone secretion. In this study, we investigated the …

Background—Aldosterone, synthesized in the adrenal cortex by the enzyme CYP11B2,
induces positive sodium balance and predisposes to hypertension. Various investigators …

The majority of genes contributing to the heritable component of blood pressure remain
unidentified, but there is substantial evidence to suggest that common polymorphisms at loci …

ABSTRACT Background and Objectives: Essential hypertension is a complex progressive
cardiovascular disorder. Renin–angiotensin aldosterone system (RAAS) plays a major role …

To determine whether-344T/C CYP11B2 promoter polymorphism affects serum aldosterone
levels and whether this polymorphism is an indicator of eGFR decline in patients with …